Innovative Photon Counting Imaging - Scientific publications



Spectral Photon-counting CT: Initial Experience with Dual–Contrast Agent Kedge Colonography. Muenzel D, Bar-Ness D, Roessl E, Blevis I, Bartels M, Fingerle AA, Ruschke S, Coulon P, Daerr H, Kopp FK, Brendel B, Thran A, Rokni M, Herzen J, Boussel L, Pfeiffer F, Proksa R, Rummeny EJ, Douek P, Noël PB.

Review of an initial experience with an experimental spectral photoncounting computed tomography system i-Mohamed S, Bar-Ness, Sigovan M, Cormode DP, Coulon P, Coche E, Vlassenbroek A, Normand G, Douek P, Boussel L.

Evaluation of spectral photon counting computed tomography K-edge imaging for determination of gold nanoparticle biodistribution in vivo Nanoscale, Si-Mohamed S, Cormode DP, Bar-Ness D, Sigovan M, Naha PC, Langlois JB, Chalabreysse L, Coulon P, Blevis I, Roessl E, Erhard K, Boussel L, Douek P.

Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner Cormode DP, Si-Mohamed S, Bar-Ness D, Sigovan M, Naha PC, Balegamire J, Lavenne F, Coulon P, Roessl E, Bartels M, Rokni M, Blevis I, Boussel L, Douek P.

Simultaneous dual-contrast multi-phase liver imaging using spectral photoncounting computed tomography: a proofof-concept study Daniela Muenzel, Heiner Daerr, Roland Proksa, Alexander A. Fingerle, Felix K. Kopp, Philippe Douek, Julia Herzen, Franz Pfeiffer, Ernst J. Rummeny and Peter B. Noël


What are the images used to diagnose and assess suspected strokes? A systematic literature review of care in four European countries. Peultier AC, Redekop K, Coche E, Severens JL.

Experimental feasibility of spectral photon-counting computed tomography with two contrast agents for the detection of endoleaks following endovascular aortic repair Dangelmaier J, Bar-Ness D, Daerr H, Muenzel D, Si-Mohamed S, Ehn S, Fingerle AA, Kimm MA, Kopp FK, Boussel L, Roessl E, Pfeiffer F, Rummeny EJ, Proksa R, Douek P, Noël PB.

Synthesis of High Relaxivity Gadolinium AAZTA Tetramers as Building Blocks for Bioconjugation Martina Tripepi, Federico Capuana, Eliana Gianolio, Flávio Vinicius Crizóstomo Kock, Amerigo Pagoto, Rachele Stefania, Giuseppe Digilio, Silvio Aime

Comparison of five one-step reconstruction algorithms for spectral CT. Mory C, Sixou B, Si-Mohamed S, Boussel L, Rit S.

Assessment of candidate elements for development of spectral photon-counting CT specific contrast agents Kim J, Bar-Ness D, Si-Mohamed S, Coulon P, Blevis I, Douek P, Cormode DP.

Multicolour imaging with spectral photon-counting CT: a phantom study Si-Mohamed, Salim and Bar-Ness, Daniel and Sigovan, Monica and Tatard-Leitman, Valérie and Cormode, David P. and Naha, Pratap C. and Coulon, Philippe and Rascle, Lucie and Roessl, Ewald and Rokni, Michal and Altman, Ami and Yagil, Yoad and Boussel, Loic and Douek, Philippe

Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging Felix K. Kopp, Heiner Daerr, Salim Si-Mohamed, Andreas P. Sauter, Sebastian Ehn, Alexander A. Fingerle, Bernhard Brendel, Franz Pfeiffer, Ewald Roessl, Ernst J. Rummeny, Daniela Pfeiffer, Roland Proksa, Philippe Douek, Peter B. Noël


Technical Note: Relative proton stopping power estimation from virtual monoenergetic images reconstructed from dual-layer computed tomography Guillaume Landry, Fabian Dörringer, Salim Si-Mohamed, Philippe Douek, Juan F P J Abascal, Françoise Peyrin, Isabel P Almeida, Frank Verhaegen, Ilaria Rinaldi, Katia Parodi, Simon Rit

Differentiation between blood and iodine in a bovine brain—Initial experience with Spectral Photon-Counting Computed Tomography Isabelle Riederer, Salim Si-Mohamed, Sebastian Ehn, Daniel Bar-Ness, Peter B. Noel, Alexander A. Fingerle, Franz Pfeiffer, Ernst J. Rummeny, Philippe Douek, Daniela Pfeiffer

A sparse and prior based method for 3D image denoising Juan F P J Abascal, S. Si-Mohamed, Philippe Douek, C. Chappard, Françoise Peyrin

Liquid Embolic Agents in Spectral X-Ray Photon-Counting Computed Tomography using Tantalum K-Edge Imaging Isabelle Riederer, Daniel Bar-Ness, Melanie A. Kimm, Salim Si-Mohamed, Peter B. Noël, Ernst J. Rummeny, Philippe Douek, & Daniela Pfeiffer Liquid Embolic

Human Knee Phantom for Spectral CT: Validation of a Material Decomposition Algorithm S Bussod, JFPJ Aascal, N Ducros; C. Olivier Si-Mohamed, Philippe Douek, C. Chappard, Françoise Peyrin

Spectral Photon-Counting Computed Tomography (SPCCT): in-vivo single-acquisition multiphase liver imaging with a dual contrast agent protocol Salim Si-Mohamed, Valérie Tatard-Leitman, Alexis Laugerette, Monica Sigovan, Daniela Pfeiffer, Ernst J. Rummeny, Philippe Coulon, Yoad Yagil, Philippe Douek, Loic Boussel & Peter B. Noël

Spectral Photon-Counting Computed Tomography for Coronary Stent Imaging Grischa Bratke, Tilman Hickethier, Daniel Bar-Ness, Alexander Christian Bunck, David Maintz, Gregor Pahn,§ Philippe Coulon, Salim Si-Mohamed, Philippe Douek and Monica Sigovan

Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo elementspecific K-edge imaging and quantification Niki Halttunen, Frederic Lerouge, Frederic Chaput, Marc Vandamme, Szilvia Karpati, Salim Si-Mohamed, Monica Sigovan, Loic Boussel, Emmanuel Chereul, Philippe Douek & Stephane Parola

Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography Yuxi C. Dong, Maryam Hajfathalian, Portia S. N. Maidment, Jessica C. Hsu, Pratap C. Naha, Salim Si-Mohamed, Marine Breuilly, Johoon Kim, Peter Chhou

Feasibility of improving vascular imaging in the presence of metallic stents using spectral photon counting CT and K-edge imaging Monica Sigovan, Salim Si-Mohamed, Daniel Bar-Ness, Julia Mitchell, Jean-Baptiste Langlois, Philippe coulon, Ewald Roessl, Ira Blevis, Michal Rokni, Gilles Rioufol, Philippe Douek & Loic Boussel


ROI-Wise Material Decomposition in Spectral Photon-Counting CT B.Q. Xie, P. Niu, T. Su, V. Kaftandjian, L. Boussel, Ph. Douek, F. Yang, Ph. Duvauchelle, Y. M. Zhu


Feasibility of human vascular imaging of the neck with a large field-of-view spectral photon-counting CT system Sara Boccalini, Salim Si-Mohamed, Riham Dessouky, Monica Sigovan, Loïc Boussel, Philippe Douek

Feasibility of lung imaging with a large field-of-view spectral photon-counting CT system Si-Mohamed, S.; Boccalini, S.; Rodesch, P.-A.; Dessouky, R.; Lahoud, E.; Broussaud, T.; Sigovan, M.; Gamondes, D.; Coulon, P.; Yagil, Y.; Boussel, L. & Douek, P.

In Vivo Molecular K-Edge Imaging of Atherosclerotic Plaque Using Photon-counting CT. Si-Mohamed, S. A.; Sigovan, M.; Hsu, J. C.; Tatard-Leitman, V.; Chalabreysse, L.; Naha, P. C.; Garrivier, T.; Dessouky, R.; Carnaru, M.; Boussel, L.; Cormode, D. P. & Douek, P. C.

Comparison of image quality between spectral photon-counting CT and dual-layer CT for the evaluation of lung nodules: a phantom study Si-Mohamed, S. A.; Greffier, J.; Miailhes, J.; Boccalini, S.; Rodesch, P.-A.; Vuillod, A.; van der Werf, N.; Dabli, D.; Racine, D.; Rotzinger, D.; Becce, F.; Yagil, Y.; Coulon, P.; Vlassenbroek, A.; Boussel, L.; Beregi, J.-P. & Douek, P.

Improved Image Reconstruction Using Multi-Energy Information in Spectral Photon-Counting CT P. Niu, L. H. Wang, B. Q. Xie, M. Robini, L. Boussel, Ph. Douek, Y. M. Zhu, F. Yang

Coronary calcium scoring potential of large field-of-view spectral photon-counting CT: a phantom study van der Werf, N. R.; Si-Mohamed, S.; Rodesch, P. A.; van Hamersvelt, R. W.; Greuter, M. J. W.; Boccalini, S.; Greffier, J.; Leiner, T.; Boussel, L.; Willemink, M. J. & Douek, P.

Diagnostic Performance of Extracellular Volume Quantified by Dual-Layer Dual-Energy CT for Detection of Acute Myocarditis Salim Aymeric Si-Mohamed, Lauria Marie Restier, Arthur Branchu, Sara Boccalini, Anaelle Congi, Arthur Ziegler, Danka Tomasevic, Thomas Bochaton, Loic Boussel and Philippe Charles Douek

First In-Human Results of Computed Tomography Angiography for Coronary Stent Assessment With a Spectral Photon Counting Computed Tomography Sara Boccalini, Salim Si-Mohamed, Hugo Lacombe, Adja Diaw, Mohammad Varasteh, Pierre-Antoine Rodesch, Marjorie Villien, Monica Sigovan, Riham Dessouky, Philippe Coulon, Yoad Yagil, Elias Lahoud, Klaus Erhard, Gilles Rioufol, Gerard Finet, Eric Bonnefoy-Cydraz, Cyrille Bergerot, Loic Boussel, & Philippe Douek

Super-Energy-Resolution Material Decomposition for Spectral Photon-Counting CT Using Pixel-Wise Learning Bingquig Xie, Yuemin Zhu, Pei Niu, Ting Su, Feng Yang, Lihui Wang, Pierre-Antoine Rodesch, Loic Boussel, Philippe Douek and Philippe Duvauchelle

Spectral Photon-Counting CT Technology in Chest Imaging Salim Si-Mohamed , Jade Miailhes, Pierre-Antoine Rodesch, Sara Boccalini, Hugo Lacombe, Valérie Leitman, Vincent Cottin, Loic Boussel , Philippe Douek

Performance of Spectral Photon-Counting Coronary CT Angiography and Comparison with Energy-Integrating-Detector CT: Objective Assessment with Model Observer David C. Rotzinger, Damien Racine, Fabio Becce, Elias Lahoud, Klaus Erhard, Salim A. Si-Mohamed, Joël Greffier, Anaïs Viry, Loïc Boussel, Reto A. Meuli, Yoad Yagil, Pascal Monnin and Philippe C. Douek


Coronary CT Angiography with Photon-counting CT: First-In-Human Results Salim A. Si-Mohamed, Sara Boccalini, Hugo Lacombe, Adja Diaw, Mohammad Varasteh, Pierre-Antoine Rodesch, Riham Dessouky, Marjorie Villien, Valérie Tatard-Leitman, Thomas Bochaton, Philippe Coulon, Yoad Yagil, Elias Lahoud, Klaus Erhard, Benjamin Riche, Eric Bonnefoy, Gilles Rioufol, Gerard Finet, Cyrille Bergerot, Loic Boussel, Joel Greffier, Philippe C. Douek

Virtual monoenergetic images from photon-counting spectral computed tomography to assess knee osteoarthritis Christine Chappard, Juan Abascal, Cécile Olivier, Salim Si-Mohamed, Loic Boussel, Jean Baptiste Piala, Philippe Douek and Francoise Peyrin

Ytterbium Nanoparticle Contrast Agents for Conventional and Spectral Photon-Counting CT and Their Applications for Hydrogel ImagingYuxi C. Dong, Ananyaa Kumar, Derick N. Rosario-Berríos, Salim Si-Mohamed, Jessica C. Hsu, Lenitza M. Nieves, Philippe Douek, Peter B. Noël, and David P. Cormode

Spectral CT imaging: Technical principles of dual-energy CT and multi-energy photon-counting CTJoël Greffier, Nicolas Villani, Didier Defez, Djamel Dabli, Salim Si-Mohamed


Optical and X-ray attenuation properties of hafnium oxide nanoparticles surface functionalized with fucoidan: toward the early diagnosis of atherothrombotic diseases Yasmine Sebti, Salim Si-Mohamed, Rachida Aid, Frederic Geinguenaud, Mohand Chalal, Yoann Lalatonne, Frederic Chaubet, Phalla Ou and Laurence Motte

Bicolor K-edge spectral photon-counting CT imaging for the diagnosis of thoracic endoleaks: A dynamic phantom study Benoit Cosset, Monica Sigovan, Sara Boccalini, Fadi Farhat, Philippe Douek, Loic Boussel, Salim Aymeric Si-Mohamed

High-resolution synchrotron K-edge subtraction CT allows tracking and quantifying therapeutic cells and their scaffold in a rat model of focal cerebral injury and can serve as a reference for spectral photon counting CT Clément Tavakoli, Elisa Cuccione, Chloé Dumot, Joëlle Balegamire, Salim Aymeric Si-Mohamed, Johoon Kim, Claire Crola-da-Silva, Yves Chevalier, Loïc Boussel, Philippe Douek, David Cormode, Hélène Elleaume, Emmanuel Brun, Marlène Wiart

First Experience With a Whole-Body Spectral Photon-Counting CT Clinical Prototype Salim A. Si-Mohamed, Sara Boccalini, Marjorie Villien, Yoad Yagil, Klaus Erhard, Loic Boussel and Philippe C. Douek

Virtual monochromatic images for coronary artery imaging with a spectral photon-counting CT in comparison to dual-layer CT systems: a phantom and a preliminary human study Joel Greffier, Salim A Si-Mohamed, Hugo Lacombe, Joey Labour, Djamel Djabli, Sara Boccalini, Mohammad Varasteh, Marjorie Villien, Yoad Yagil, Klaus Erhard, Loic Boussel, Jean-Paul Beregi, Philippe C Douek

Gadolinium K-edge angiography with a spectral photon counting CT in atherosclerotic rabbits Sara Boccalini, Riham Dessouky, Pierre-Antoine Rodesch, Hugo Lacombe, Yoad Yagil, Elias Lahoud, Klaus Erhard, Bernhard Brendel, Philippe Coulon, Jean-Baptiste Langlois, Frederic Chaput, Stephane Parola, Loic Boussel, Frederic Lerouge, Salim Si-Mohamed, Philippe C Douek

Quantification of cartilage and subchondral bone cysts on knee specimens based on a spectral photon‑counting computed tomography Célestin Garcelon, Juan Abascal, Cecile Olivier, Stéphanie Uk, Salim Si‑Mohamed, Hang‑Korng Ea, Philippe Douek, Francoise Peyrin & Christine Chappard

Le présent et l’avenir en pathologie interstitielle pulmonaire: The present and future of explorations in interstitial lung disease Article rédigé par K. El Husseini d’après les interventions de S. Jouneau, L. Wemeau et S. Si-Mohamed

Spectral dual-energy CT: A new tool to monitor lung perfusion recovery in acute pulmonary embolism after mechanical thrombectomy Lorraine Martineau, Arthur Branchu, Sara Boccalini, Loïc Boussel, Philippe Douek, Salim A. Si-Mohamed

Comprehensive Imaging of Coronary Stent Using Ultra-High Resolution Spectral Photon Counting CT - A Multimodality Validation Guillaume Fahrni, Sara Boccalini, Cyril Prieur, Philippe Douek, Salim A. Si-Mohamed

Clinical Applications of Photon-counting CT: A Review of Pioneer Studies and a Glimpse into the Future Philippe C. Douek, Sara Boccalini, Edwin H. G. Oei, David P. Cormode, Amir Pourmorteza, Loic Boussel, Salim A. Si-Mohamed, Ricardo P. J. Budde

Low-iodine 40-keV virtual monoenergetic CT angiography of the lower extremities Guillaume Fahrni, Thomas Mingas, Arthur Deliessche, Smail Hraichi, David C. Rotzinger, Salim A. Si-Mohamed, Sara Boccalini and Philippe Douek

NEW! Comparison of two deep-learning image reconstruction algorithms on cardiac CT images: A phantom study Joël Greffier, Maxime Pastor, Salim Si-Mohamed, Cynthia Goutain-Majorel, Aude Peudon-Balas,Mourad Zoubir Bensalah,Julien Frandon,Jean-Paul Beregi, Djamel Dabli

NEW! Image quality improvement of a one-step spectral CT reconstruction on a prototype photon-counting scanner Pierre-Antoine Rodesch, Salim A Si-Mohamed, Jérôme Lesaint, Philippe C Douek and Simon Rit

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